May 2020. In this review article we highlight the importance of investigating how the extracellular matrix directly and indirectly impacts tumor-associated macrophage activation. Recent advances in investigating macrophages in the tumor microenvironment and future directions …
Month: May 2020
The Ponik and Weaver labs publish new study on a live cell reporter of exosomes
April 2020. The finding of this study, published in Nature Communications, demonstrates through dynamic monitoring of EVs that exosomes are secreted at the front of migrating cells and left behind in exosome trails. We also …
Ponik Lab publishes new study on MMP-mediated crosstalk from stromal fibroblasts to promote breast cancer cell 3D migration
May 2020. In this study, published in Cancers – Special Issue on Tumor Stroma, a microfluidic model was used to study the effect of 3D heterogeneous ECMs (i.e., fibroblasts and different ECM protein compositions) on …