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Ponik Lab
Department of Cell and Regenerative Biology
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Ponik Lab News & Events

Ponik Lab publishes study on directional cues in the tumor microenvironment

Posted on May 7, 2021

May 2021. In this study we developed innovative methodology to discover that collagen alignment results in a 35-fold difference in cell-scale stiffness and alters contractile force transmission through the fiber network. Furthermore, we identified bias …

Posted in Ponik Lab News & Events

Ponik Lab Welcomes New Students!

Posted on December 18, 2020

December 2020: The Ponik lab welcomees two new graduate students. Metti Gari is a student in the Molecular and Cellular Pharmacology Program and Shelby Fertal is in the Endocrinology and Reproductive Physiology Program.  We are …

Posted in Ponik Lab News & Events

Congratulations to Erica Hoffmann!

Posted on August 7, 2020

August 2020 – Ponik lab grad student, Erica Hoffmann, successfully completed her prelim exam, “The Regulation of Tumor-Associated Macrophages by a Collagen-Dense Breast Tumor Microenvironment”. She is now a dissertator in the Molecular and Cellular …

Posted in Ponik Lab News & Events

Ponik Lab publishes review article on biomechanical activation of tumor associated macrophages

Posted on May 20, 2020

May 2020.  In this review article we highlight the importance of investigating how the extracellular matrix directly and indirectly impacts tumor-associated macrophage activation. Recent advances in investigating macrophages in the tumor microenvironment and future directions …

Posted in Ponik Lab News & Events

The Ponik and Weaver labs publish new study on a live cell reporter of exosomes

Posted on May 6, 2020

April 2020.  The finding of this study, published in Nature Communications, demonstrates through dynamic monitoring of EVs that exosomes are secreted at the front of migrating cells and left behind in exosome trails. We also …

Posted in Ponik Lab News & Events

Ponik Lab publishes new study on MMP-mediated crosstalk from stromal fibroblasts to promote breast cancer cell 3D migration

Posted on May 6, 2020

May 2020.  In this study, published in Cancers – Special Issue on Tumor Stroma, a microfluidic model was used to study the effect of 3D heterogeneous ECMs (i.e., fibroblasts and different ECM protein compositions) on …

Posted in Ponik Lab News & Events

Collaboration with Dr. Schuler highlighted in Extracellular Matrix News

Posted on September 4, 2019

Dynamic interactions between the extracellular matrix and estrogen activity in progression of ER+ breast cancer.   Oncogene. 2019 Aug 12

Posted in Ponik Lab News & Events

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